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Shares in issue & significant shareholders

Number of shares in issue

As of 30 September 2018 the Company’s issued share capital consists of 303,309,707 Ordinary shares with a nominal value of 0.001 pence each (“Ordinary shares”), each share having equal voting rights therefore the number of Ordinary shares with voting rights is 303,309,707.

As at 30 September 2018 the following interests of shareholders in excess of 3% have been notified to the Company.

Significant shareholders

Manager

Origin

Holdings

%

Invesco Perpetual

UK

88,670,000

29.2

Woodford Investment Management

UK

74,980,042

24.7

Forward Innovation Fund

UK

34,072,336

11.2

Baillie Gifford

UK

16,725,778

5.7

Forward Nominees Limited

UK

16,481,456

5.4

NFU

UK

13,860,000

4.6

In accordance with the AIM Rule 26 in so far as the Company is aware, as at 30 September 2018 the percentage of the Company’s issued share capital that is not in public hands is 76.8%.

Details of any restrictions on the transfer of securities

There are no restrictions on the transfer of securities.

Details of any other exchange or trading platforms

The Company operates on no other exchanges or trading platforms other than AIM.

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